Geometry-driven migration efficiency of autonomous epithelial cell clusters

Eléonore Vercurysse, David B. Brückner, Manuel Gómez-González, Alexandre Remson, Marine Luciano, Yohalie Kalukula, Leone Rossetti, Xavier Trepat, Edouard Hannezo and Sylvain Gabriele

bioRxiv https://www.biorxiv.org/content/10.1101/2022.07.17.500364v2.abstract (2023)

A minimal physical model for curvotaxis driven by curved protein complexes at the cell's leading edge

Raj Kumar Sadhu, Marine Luciano, Wang Xi, Cristina Martinez Torres, Marcel Schroder, Christoph Blum, Marco Tarantola, Samo Penic, Ales Iglic, Carsten Beta, Oliver Steinbock, Eberhard Bodenschatz, Benoit Ladoux, Sylvain Gabriele, Nir Gov

bioRxiv https://www.biorxiv.org/content/10.1101/2023.04.19.537490v1 (2023)

Stretch-injury promotes activation of microglia with enhanced phagocytic and synaptic stripping activities

Anthony Procès, Yeranddy A. Alpizar, Sophie Halliez, Bert Brône, Frédéric Saudou, Laurence Ris and Sylvain Gabriele

Biomaterials 305, 122426 (2024)

Mechanoresponse of Curved Epithelial Monolayers Lining Bowl-Shaped 3D Microwells

Marine Luciano, Marie Versaevel, Yohalie Kalukula and Sylvain Gabriele

Advanced Healthcare Materials, Early View on line (2023)

Translating cell mechanobiology and nuclear deformations to the clinic

Yohalie Kalukula, Marine Luciano and Sylvain Gabriele

Clinical and Translational Medicine 12, e1000 (2022)

Keratocytes migrate against flow with a roly-poly-like mechanism

Valentine Seveau de Noray, Fabio Manca, Inès Mainil, Alexandre Remson, Martine Biarnes-Pelicot, Sylvain Gabriele, Marie-Pierre Valignat, and Olivier Theodoly

Proceedings of the National Academy of Sciences 119, e2210379119 (2022)

Mechanics and functional consequences of nuclear deformations

Yohalie Kalukula, Andrew D Stephens, Jan Lammerding and Sylvain Gabriele

Nature Reviews Molecular Cell Biology (2022)

Highlighted in national newspapers: rtbf.be, La Libre.be and dhnet.be

Invited by Fabienne Vande Meerssche for a radio interview on “Les Eclaireurs - La Premiere” : LINK

Multiscale mechanobiology in brain physiology and diseases

Anthony Procès, Marine Luciano, Yohalie Kalukula, Laurence Ris and Sylvain Gabriele

Frontiers in Cell and Developmental Biology 10, 823857 (2022)

Appreciating the role of cell shape changes in the mechanobiology of epithelial tissues

Marine Luciano, Marie Versaevel, Eléonore Vercruysse, Anthony Procès, Yohalie Kalukula, Alexandre Remson, Amandine Deridoux, Sylvain Gabriele

Biophysics Reviews 3, 011305 (2022)

Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo

Wallis Nahaboo, Sema Elif Eski, Evangéline Despin-Guitard, Marjorie Vermeersch, Marie Versaevel, Bechara Saykali, Daniel Monteyne, Sylvain Gabriele, Thomas M. Magin, Nicole Schwarz, Rudolf Leube, An Zwijsen, David Perez-Morga, Sumeet Pal Singh, Isabelle Migeotte

EMBO Journal e108747 (2022)

Cell monolayers sense curvature by exploiting active mechanics and nuclear mechanoadaptation

Marine Luciano, Shi-Lei Xue, Winnok H De Vos, Lorena Redondo-Morata, Mathieu Surin, Frank Lafont, Edouard Hannezo, Sylvain Gabriele

Nature Physics 17, 1382-1390 (2021)

Highlighted in PreLights, ScienceDaily, PhysOrg, MirageNews, ErakAlert!, …

Inflammatory Molecules Released by Mechanically Injured Astrocytes Trigger Presynaptic Loss in Cortical Neuronal Networks

Joséphine Lantoine, Anthony Procès, Agnès Villers, Sophie Halliez, Luc Buée, Laurence Ris, Sylvain Gabriele

ACS Chemical Neuroscience 12, 20, 3885–3897 (2021)

Collective migration during a gap closure in a two-dimensional haptotactic model

Marie Versaevel, Laura Alaimo, Valentine Seveau, Marine Luciano, Danahe Mohammed, Céline Bruyère, Eléonore Vercruysse, Olivier Théodoly, Sylvain Gabriele

Scientific reports 11, 1-11 (2021)

Engineering slit‐like channels for studying the growth of epithelial tissues in 3D‐confined spaces

Laura Alaimo, Marine Luciano, Danahe Mohammed, Marie Versaevel, Céline Bruyère, Eléonore Vercruysse, Sylvain Gabriele

Biotechnology and Bioengineering 117, 2887-2896 (2020)

Producing collagen micro-stripes with aligned fibers for cell migration assays

Danahe Mohammed, Gaspard Pardon, Marie Versaevel, Céline Bruyère, Laura Alaimo, Marine Luciano, Eléonore Vercruysse, Beth L Pruitt, Sylvain Gabriele

Cellular and Molecular Bioengineering 13, 87-98 (2020)

Front cover of the Feb 2020 issue of Cellular and Molecular Bioengineering

Actomyosin contractility scales with myoblast elongation and enhances differentiation through YAP nuclear export

Céline Bruyère, Marie Versaevel, Danahe Mohammed, Laura Alaimo, Marine Luciano, Eléonore Vercruysse, Sylvain Gabriele

Scientific Reports 9, 1-14 (2019)

Kinked silicon nanowires: superstructures by metal-assisted chemical etching

Georgiana Sandu, Jonathan Avila Osses, Marine Luciano, Darwin Caina, Antoine Stopin, Davide Bonifazi, Jean-François Gohy, Alejandro Silhanek, Ileana Florea, Mounib Bahri, Ovidiu Ersen, Philippe Leclère, Sylvain Gabriele, Alexandru Vlad, Sorin Melinte

Nano Letters 11, 7681-7690 (2019)

Substrate area confinement is a key determinant of cell velocity in collective migration

Danahe Mohammed, Eléonore Vercruysse, Marie Versaevel, Joséphine Lantoine, Laura Alaimo, Céline Bruyère, Marine Luciano, Karine Glinel, Geoffrey Delhaye, Olivier Théodoly, Sylvain Gabriele

Nature Physics 15, 858-866 (2019)

Highlighted in PhysOrg, Daily Science, DH journal, …

Innovative tools for mechanobiology: unraveling outside-in and inside-out mechanotransduction

Danahe Mohammed, Marie Versaevel, Céline Bruyère, Laura Alaimo, Marine Luciano, Eléonore Vercruysse, Anthony Procès, Sylvain Gabriele

Frontiers in Bioengineering and Biotechnology 7, 162 (2019)

Supramolecular Self-Assembly of DNA with a Cationic Polythiophene: From Polyplexes to Fibers

Maxime Leclercq, Jenifer Rubio‐Magnieto, Danahe Mohammed, Sylvain Gabriele, Laurent Leclercq, Hervé Cottet, Sébastien Richeter, Sébastien Clément, Mathieu Surin

Frontiers in Bioengineering and Biotechnology 5, 703-709 (2019)

Front cover of the June 2019 issue of ChemNanoMat

Live nanoscopic to mesoscopic topography reconstruction with an optical microscope for chemical and biological samples

Olivier Theodoly, Nicolas Garcia-Seyda, Fréderic Bedu, Xuan Luo, Sylvain Gabriele, Tâm Mignot, Joanna Giermanska, Jean-Paul Chapel, Mélinda Métivier, Marie-Pierre Valignat

PLoS ONE 13, e0207881 (2018)

Deregulation of focal adhesion formation and cytoskeletal tension due to loss of A-type lamins

Tobias DJ Corne, Tom Sieprath, Jonathan Vandenbussche, Danahe Mohammed, Mariska Te Lindert, Kris Gevaert, Sylvain Gabriele, Katarina Wolf, Winnok H De Vos

Cell adhesion & Migration 11, 447-463 (2017)

A new method allowing long‐term potentiation recordings in hippocampal organotypic slices

Paula Paci, Sylvain Gabriele, Laurence Ris

Brain and Behavior 7, e00692 (2017)

Probing cytoskeletal pre-stress and nuclear mechanics in endothelial cells with spatiotemporally controlled (de-) adhesion kinetics on micropatterned substrates

Marie Versaevel, Maryam Riaz, Tobias Corne, Thomas Grevesse, Joséphine Lantoine, Danahe Mohammed, Céline Bruyère, Laura Alaimo, Winnok H De Vos, Sylvain Gabriele

Cell Adhesion & Migration 11, 98-109 (2017)

Persistence of fan-shaped keratocytes is a matrix-rigidity-dependent mechanism that requires α5β1 integrin engagement

Maryam Riaz, Marie Versaevel, Danahe Mohammed, Karine Glinel, Sylvain Gabriele

Scientific Reports 6, 1-14 (2016)

Matrix stiffness modulates formation and activity of neuronal networks of controlled architectures

Joséphine Lantoine, Thomas Grevesse, Agnes Villers, Geoffrey Delhaye, Camille Mestdagh, Marie Versaevel, Danahe Mohammed, Céline Bruyere, Laura Alaimo, Stéphanie P Lacour, Laurence Ris, Sylvain Gabriele

Biomaterials 89, 14-24 (2016)

Click reactive microgels as a strategy towards chemically injectable hydrogels

Rémi Absil, Seda Çakir, Sylvain Gabriele, Philippe Dubois, Christopher Barner-Kowollik, Filip Du Prez, Laetitia Mespouille

Polymer Chemistry 7, 67-52 (2016)

Dissecting the mechanical behavior of neuronal microcompartments by combining magnetic tweezers and protein micropatterns

Thomas Grevesse, Joséphine Lantoine, Geoffrey Delhaye, Sylvain Gabriele

Neuroscience Communications 1, e1003 (2015)

Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury

Thomas Grevesse, Borna E Dabiri, Kevin Kit Parker, Sylvain Gabriele

Scientific Reports 5, 1-10 (2015)

Highlighted in Daily Science and in FNRS News (June 2015)

Super-resolution microscopy reveals LINC complex recruitment at nuclear indentation sites

Marie Versaevel, Jean-Baptiste Braquenier, Maryam Riaz, Thomas Grevesse, Joséphine Lantoine, Sylvain Gabriele

Scientific reports 4, 1-8 (2014)

Preparation of hydroxy-PAAm hydrogels for decoupling the effects of mechanotransduction cues

Thomas Grevesse, Marie Versaevel, Sylvain Gabriele

Journal of Visualized Experiments 90, 51010 (2014)

Micropatterning hydroxy-PAAm hydrogels and Sylgard 184 silicone elastomers with tunable elastic moduli

Marie Versaevel, Thomas Grevesse, Maryam Riaz, Joséphine Lantoine, Sylvain Gabriele

Methods in Cell Biology 121, 33-48 (2014)

Micropatterning in Cell Biology Part C, edited by Matthieu Piel and Manuel Théry

A simple route to functionalize polyacrylamide hydrogels for the independent tuning of mechanotransduction cues

Thomas Grevesse, Marie Versaevel, Géraldine Circelli, Sylvain Desprez, Sylvain Gabriele

Lab on a Chip 13, 777-780 (2013)

Cell confinement: putting the squeeze on the nucleus

Marie Versaevel, Maryam Riaz, Thomas Grevesse, Sylvain Gabriele

Soft Matter 39, 6665-6676 (2013)

Special Theme Issue on Emerging Investigators in Soft Matter

Passive circulating cell sorting by deformability using a microfluidic gradual filter

Pascal Preira, Véronique Grandne, J-M Forel, Sylvain Gabriele, M Camara, Olivier Theodoly

Lab on a Chip 13, 161-170 (2013)

Spatial coordination between cell and nuclear shape within micropatterned endothelial cells

Marie Versaevel, Thomas Grevesse, Sylvain Gabriele

Nature Communications 3, 1-11 (2012)

Selected by Faculty of 1000 Biology as “must read” article, selected as “featured image of the week” by Nature Communications, FNRS Magazine (June 2012), Athena Magazine (may 2012), Le Soir journal (april 2012)

A possible role for integrin signaling in diffuse axonal injury

M.A. Hemphill*, B.E. Dabiri*, S. Gabriele*, L. Kerscher, C. Franck, J.A. Goss, P.W. Alford and K.K. Parker
*These authors contributed equally to this work

PLoS ONE, 6, E22899 (2011)

Highlighted in Nature : Bomb-blast brain injuries explained, Nature News, july 22, 2011, Science: How Blasts Injure the Brain, Science News (july 22, 2011), MIT Technology Reviews: The Mechanics of Blast Injury, Biomedicine (july 22, 2011), HARVARD gazette: New approaches to Traumatic Brain Injuries, Health & Medicine (july 25, 2011), FNRS News Magazine, L’effet de souffle d’une explosion, 87, 28-29 (December 2011), Le Soir (national newspaper), Comment le cerveau explose (sept 20, 2011), La Province, Effet de souffle: UMons et Harvard découvrent (sept 21, 2011), Sciencedaily: Bioengineers identify the cellular mechanisms of TBI, Science News (july 22, 2011), Sciencenewsline (july 22, 2011), e! Science News (july 22, 2011, EurekAlert! (july 22, 2011), Biomechanisms.com (july 24, 2011), Labmate-online.com (july 25, 2011), The Behavorial Medicine Report (july 23, 2011), medicalxpress.com (july 23, 2011), FirstScience.com (july 22, 2011), psypost.org (july 25, 2011), physorg.com (july 23, 2011), ebionews.com (july 25, 2011), etc.

Influence of chain interdiffusion between immiscible poymers on dewetting dynamics

S. Coppée, S. Gabriele, A.-M. Jonas, J. Jestin and P. Damman

Soft Matter, 7, 9951-9955 (2011)

A simple microfluidic method to select, isolate, and manipulate single-cells in mechanical and biochemical assays

S. Gabriele, M. Versaevel, P. Preira and O. Theodoly

Lab on a Chip, 10, 1459-1467 (2010)

Hierarchical wrinkling patterns

H. Vandeparre*, S. Gabriele*, F. Brau, C. Gay, K.K. Parker and P. Damman
*These authors contributed equally to this work

Soft Matter, 6, 5751-5756 (2010)

Microfluidic investigation reveals distinct roles for actin cytoskeleton and myosin II activity in capillary leukocyte trafficking

S. Gabriele, A.-M. Benoliel, P. Bongrand and O. Theodoly

Biophysical Journal, 96, 4308-4318 (2009)

Dewetting as an investigative tool for studying properties in thin polymer films

G. Reiter, S. Al Akrass, M. Hamieh, P. Damman, S. Gabriele, T. Vilmin and E. Raphaël

The European Physical Journal, Special Topics, 166, 165-172 (2009)

On the mechanics of rim instabilities in viscoelastic polymer thin films

S. Gabriele, S. Coppée, G. Reiter and P. Damman

The European Physical Journal, Special Topics, 166, 55-61 (2009)

Cover of the Special Issue on « Recent Advances in Coating and Dynamical Wetting »

Influence of surface reflective properties on DIC microscopy

O. Theodoly, S. Gabriele and M.P. Valignat

Optics Express, 16, 4547-4558 (2008)

Relaxation of residual stress and reentanglement of polymers in spin-coated films

P. Damman, S. Gabriele, S. Coppée, S. Desprez, D. Villers, T. Vilmin, E. Raphaël, M. Hamieh, S. Al Akrass and G. Reiter

Physical Review Letters, 99, 036101 (2007)

Influence of substrate properties on the dewetting dynamics of viscoelastic polymer films

M. Hamieh, S. Al Akrass, T. Hamieh, P. Damman, S. Gabriele, T. Vilmin, E. Raphaël and G. Reiter

The Journal of Adhesion, 83, 367-381 (2007)

Viscoelastic dewetting of constrained polymer thin films

S. Gabriele, P. Damman, S. Sclavons, S. Desprez, S. Coppée, G. Reiter, M. Hamieh, S. Al Akrass, T. Vilmin and E. Raphaël

Journal of Polymer Science Part B: Polymer Physics, 44, 3022-3030 (2006)

Disentanglement time of polymers determines the onset of rim instabilities in dewetting

S. Gabriele, S. Sclavons, G. Reiter and P. Damman

Physical Review Letters, 96, 156105 (2006)

The role of non-linear friction in the dewetting of thin polymer films

T. Vilmin, E. Raphaël, P. Damman, S. Sclavons, S. Gabriele, M. Hamieh and G. Reiter

Europhysics Letters, 73, 906-912 (2006)

Residual stresses in thin polymer films cause rupture and dominate early stages of dewetting

G. Reiter, M. Hamieh, P. Damman, S. Sclavons, S. Gabriele, T. Vilmin and E. Raphaël

Nature Materials, 4, 754-758 (2005)

Nanorubbing of polythiophene surfaces

G. Derue, S. Coppée, S. Gabriele, M. Surin, V. Geskin, F. Monteverde, P. Leclère, R. Lazzaroni and P. Damman

Journal of the American Chemical Society, 127, 8018-8019 (2005)